|
Mark S. Pian, M.D.
Education:
|
1973-77
|
Revelle College, University of California, San Diego, CA.
B.A., Biology, magna cum laude |
| 1978-82 |
University of California, Los Angeles, CA.
M.D., Medicine |
| 1982-83 |
University of Washington, Children's Orthopedic Hospital, Seattle, WA. Intern, Pediatrics |
| 1983-85 |
University of Washington, Children's Orthopedic Hospital, Seattle, WA. Resident, Pediatrics |
| 1985-88 |
Dept. of Pediatrics, University of California, Clinical Fellow, Pediatrics, San Francisco, CA, Pulmonology. |
| 1985-88 |
Cardiovascular Research Institute. University of California, Research Fellow Pediatric, San Francisco, CA. Pulmonology |
Licenses, Certifications, Etc:
| 1985 |
Medical license, California |
| 1988 |
American Board of Pediatrics |
| 1989 |
American Board of Pediatrics, Subspecialty in Pediatric Pulmonology |
Principal Postitions Held:
| 1988-97 |
University of California, San Francisco, CA - Asst. Clinical Prof. of Pediatrics |
| 1997- |
University of California, San Diego, CA - Assoc. Clinical Prof. of Pediatrics |
Ancillary Positions Held Concurrently:
| 1984-1985 |
Airlift Northwest, Seattle, WA. Emergency Transport Physician |
| 1985 |
University of Washington, Children's Orthopedic Hospital, Seattle, WA. Assistant Chief Resident |
| 1985-97 |
Mt. Zion Hospital, San Francisco, CA Staff Pediatrician |
| 1989-97 |
Scenic General Hospital, Modesto, CA Staff Pediatrician |
| 1990-97 |
University of California, San Francisco, CA
Director, Pediatric Bronchoscopy Service |
| 1991-97 |
Natividad Medical Center, Salinas, CA
Staff Pediatrician |
| 1991-97 |
University of California, San Francisco, CA Director, Pediatric Pulmonary Training Program |
| 1997-2000 |
University of California, San Diego, CA
Assoc. Director, Cystic Fibrosis Center |
| 2000 |
University of California, San Diego, CA
Director, Cystic Fibrosis Center |
| 2000 |
University of California, San Diego, CA
Director, Pediatric Pulmonary Division |
Honors and Awards:
| 1980 |
Medical Student Research Fellowship |
| 1981 |
Alpha Omega Alpha Honor Society |
| 1982 |
Merck Book Award |
| 1988-93 |
Clinical Investigator Award, National Institutes of Health,
National Heart, Lung, and Blood Institute |
| 1994-96 |
American Lung Association Research Grant |
| 1994-99 |
Program Project Grant, National Institutes of Health, National Heart, Lung, and Blood Institute, Project Co-leader
|
| 1997-99 |
California Lung Association Research Grant |
Memberships in Professional Organizations:
| 1990 |
American Thoracic Society; Respiratory Cell and Molecular Biology Assembly
|
| 1992 |
Western Society for Pediatric Research |
| 1992 |
American Association for the Advancement of Science |
| 1992 |
American Society for Cell Biology |
| 1993-97 |
Pediatric Pulmonary Training Director's Association (PEPTDA) |
Professional Organization Activities:
| 1990 |
Cystic Fibrosis Foundation Research Development Program ad hoc reviewer |
| 1993 |
Pediatric Pulmonary Training Director's Association Curriculum Committee |
| 1995 |
American Society for Cell Biology Congressional Liaison Committee |
| 2001 |
Cystic Fibrosis Foundation, San Diego Chapter Board of Directors |
Service to Professional Publications:
| 1990 |
American Journal of Physiology: Lung Cellular and Molecular Biology reviewer
|
| 1991 |
American Journal of Respiratory Cell and Molecular Biology |
| 1992 |
Biochimica et Biophysica, Acta |
| 1994 |
American Journal of Medical Sciences |
| 1994 |
Pediatric Pulmonology |
Invited Papers, Lectures, Presentations:
| 1985 |
UCSF School of Nursing, "Upper Airway Obstruction" |
| 1987 |
Scenic General Hospital, Modesto, CA, "Cystic Fibrosis" |
| 1988 |
San Francisco General Hospital, Pediatric Grand Rounds, "SIDS and Apnea" |
| 1988 |
UCSF Pediatric Bronchoscopy Course, "Special Techniques for High Risk Patients" |
| 1989 |
UCSF Pediatric Grand Rounds, "Update on Surfactant" |
| 1990 |
University of Washington Pulmonary Biology Research Seminar, "Control of Surfactant Secretion in Isolated Alveolar Type II cells" |
| 1990 |
Cardiovascular Research Institute Pulmonary Biology Research Conference, "G Protein- Mediated Regulation of Surfactant Secretion" |
| 1991 |
Children's Hospital of Philadelphia Pulmonary Research Seminar, "G Protein-Mediated Inhibition of Surfactant Secretion in Alveolar Type II Cells From Adult Rats". |
| 1991 |
Natividad Medical Center, Salinas, CA, "Airway Emergencies" |
| 1992 |
American Thoracic Society Symposium "Exocytosis: Control at Multiple Levels" (invited speaker) |
| 1992 |
Fourth International Symposium on Surfactant, "Surfactant secretion is tonically inhibited by a G protein-mediated process in rat alveolar type II cells." Marburg, Germany 1992 (scheduled speaker) |
| 1993 |
Cardiovascular Research Institute Pulmonary Biology Research Conference, "bg Potentiates a Gs-Stimulated Increase in Adenylyl Cyclase Activity in Primary Cultures of Pulmonary Alveolar Type II Cells" |
| 1994 |
UCSF Pediatric Grand Rounds, "Acute Lung Injury" |
| 1994 |
Department of Pediatrics Faculty Research Lecture Series, "Cross Talk Between Adenylyl Cyclase-Regulating Signal Transduction Pathways" |
| 1995 |
American Pediatric Society/Society for Pediatric Research Neonatal Pulmonology Platform Presentation, "Evidence that G Proteins Regulate Apolipoprotein-stimulated Phospholipid Secretion in Alveolar Type II Cells" |
| 1995 |
UCSF Pediatric Grand Rounds, "Fiberoptic Bronchoscopy in Pediatric Patients" |
| 1995 |
University of California San Diego Pediatric Grand Rounds, "Fiberoptic Bronchoscopy in Pediatric Patients" |
| 1996 |
Children's Hosptal Oakland Research Institute Research Seminar, "Secretion and Uptake of Surfactant in Pulmonary Alveolar Type II Cells"; Modulation by Lipoproteins" |
| 1996 |
UCSF Pulmonary Research Group Scientific Meeting at Asilomar featured speaker, "Lipoprotein-Stimulated Secretion in Pulmonary Alveolar Type II Cells" |
| 1997 |
National Sickle Cell Foundation, Acute Chest Study Group invited speaker, "Surfactant Dysfunction and Lung Injury: Possible Implications for Sickle Cell Acute Chest Syndrome" |
| 1998 |
Current Concepts in Pediatric Respiratory Diseases, Course Faculty Speaker, "Flexible Bronchoscopy" |
| 1998 |
Fifth International Symposium on Surfactant, "Scavenger receptor (SR-BI) expression in alveolar type II cells; potential role in lipoprotein-stimulated surfactant secretion." Marburg, Germany |
| 2000 |
Visiting Professor, "Cystic Fibrosis; Current Practice and Future Directions", Children's Hospital of Munich; Munich, Germany |
| 2001 |
Invited Speaker, "Inhaled Antibiotics in Cystic Fibrosis; the American Experience" Symposium on Cystic Fibrosis, Berlin, Germany |
| 2001 |
Current Concepts in Pediatric Respiratory Diseases, Course Faculty, "Lung abscess and empyema" & "Bronchoscopy in immunocompromised children" |
University Service:
| 1988 |
Pediatric housestaff selection, interviewer |
| 1989-90 |
Search Committee for recruitment of junior faculty in pediatric pulmonary medicine |
| 1992 |
Search Committee for recruitment of junior faculty in pediatric pulmonary medicine |
| 1993 |
Search Committee for recruitment of junior faculty in pediatric allergy |
| 1995-97 |
Divisional Representative, Department of Pediatrics Quality Assurance Committee |
| 1997 |
ad hoc UCSD School of Medicine Committee on Academic Personnel |
| 1998 |
UCSD Department of Pediatrics Housestaff Selection Committee |
| 1999 |
UCSD Department of Pediatrics Training Program Curriculum Committee |
| 1999 |
UCSD School of Medicine Recruitment and Admissions Committee (RAC) |
| 1999 |
Ad Hoc UCSD School of Medicine Recruitment and Admissions Committee |
| 2000 |
UCSD School of Medicine Electives Committee |
| 2000 |
Mentor, UCSD School of Medicine Medical Scholars Program |
| 2001 |
Chair, Ad Hoc UCSD School of Medicine Recruitment and Admissions Committee (for faculty) |
Teaching:
Formal Teaching:
| 1985-97 |
UCSF Pediatric House Staff Noon Lecture Series |
| 1991-97 |
Pediatric Pulmonary Core Curriculum (organize weekly course) |
| 1992 |
Supervision of residents and medical students on Pediatric Pulmonary Elective |
| 1992-1993 |
As director of fellowship training, completed accreditation process for the Pulmonary Training Program through the Accreditation Council for Graduate Medical Education |
| 1993-97 |
Pediatric Bronchoscopy Review Conference |
| 1994-97 |
Lecturer: Pediatrics 140.22H, Developmental Cardiopulmonary Pathophysiology |
| 1999 |
Lecturer: UCSD Pediatrics Training Program, monthly lectures on pulmonary topics |
| 2000 |
Course Co-Director and Founder, New 4th Year School of Medicine Core Course "Bridging Principles and Practice". |
Informal Teaching:
1985 - Pediatric Pulmonary Attending
1991-97 - Ukiah and Salinas Outreach Clinics
1992 - General Pediatric Attending UCSF
1998 - Teaching Attending, Children's Hospital of San Diego
1998 - General Pediatric Attending UCSD
Postdoctoral Fellows Supervised:
1988-89 - Deborah K. Froh, M.D.
1988-94 - Debra Iannuzzi, M.D.
1988-93 - Frederick H. Royce, M.D.
1990-93 - Alan J. Adler, M.D.
1990-94 - Marsha Thompson, M.D., Ph.D.
1993-96 - Joseph Rosenecker, M.D.
1995-97 - Claudia Ordoñez, M.D.
Original Articles:
1988 Pian, M.S., Dobbs, L.G. and Duzgunes, N. Positive correlation between cytosolic free calcium and surfactant secretion in cultured alveolar type II Cells. Biochim., Biophys., Acta, 860 (1), 43-53
1988 Teague, W.G., Pian, M.S., Heldt, G.P., and Tooley, W.H., Acute reduction in Fi02 increases airways constriction in infants with chronic lung disease. Am. Rev. Respir. Dis., l37, 861-865
1992 Debs, R., Pian, M., Gaensler, K., Clements J., Friend, D., and Dobbs, L. Prolonged transgene expression in rodent lung cells. Am. J. Respir. Cell Mol. Biol. 7, 406-413
1994 Pian, M.S., Dobbs, L.G. Activation of G proteins may inhibit or stimulate surfactant secretion in rat alveolar type II cells. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L375-L381
1995 Pian, M.S., and Dobbs, L.G. Evidence for Gbg-mediated cross talk in primary cultures of lung alveolar cells: Pertussis toxin-sensitive production of cAMP. J. Biol. Chem., 270 (13) 7427-7430
1996 Pittet, J.F., Hashimoto, S, Pian, M., McElroy, M.C., Nitenberg, G, and Wiener-Kronish, J. P. Exotoxin A stimulates fluid reabsorption from distal airspaces of lung in anesthetized rats. Am. J. Physiol. 270 (Lung Cell. Mol. Physiol. 14): L232-L241
1997 Dobbs, L.G., Pian, M.S., Maglio, M., Dumars, S., and Allen, L. Maintenance of the differentiated type II cell phenotype by culture with an apical air surface. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L347-L354
1997 Pian, M.S., and Dobbs, L.G. Lipoprotein-stimulated surfactant secretion in alveolar type II cells: mediation by heterotrimeric G proteins. Am. J. Physiol. 273 (Lung Cell. Mol. Physiol. 17): L634-L639
1999 McElhinney, D.B., Reddy, V.M., Pian, M.S., Moore, P., Hanley, F.L. Compression of the central airways by a dilated aorta in infants and children with congenital disease. Annals of Thoracic Surgery, 67(4) 1130-1136
Book Chapters:
1990 Dobbs, L.G., Wïrtz, H., Pian, M.S. Regulation of surfactant secretion in cultured type-II cells. Proceedings of Third International Conference on Surfactant. Prog. Respir. Research, 25, 115-121.
1994 Pian, M.S., Dobbs, L.G. Surfactant Secretion is tonically inhibited by a G protein- mediated process in rat alveolar type II cells. Lung Surfactant: Basic Research in the Pathogenesis of Lung Disorders. Prog. Respir. Research, 27, 113-116.
Abstracts:
1984 Pian, M.S., Redding, G., Sanders, J., and Springmeyer S. Effects of bone marrow transplantation upon lung growth in adolescents with aplastic anemia. Am. Rev. Respir. Dis. l29: a212
1986 Pian, M.S., and Dobbs, L.G. Cytosolic free calcium ion concentration increases in rat alveolar type II cells treated with the ionophore A23187. Am. Rev. Respir, Dis. 133: a392
1988 Pian, M.S., and Dobbs, L.G. Surfactant secretion stimulated in cultured rat alveolar type-II cells correlates with levels of cytosolic free calcium. FASEB J. 2 (5): a957
1989 Pian, M.S., Dobbs L.G. Inhibition of surfactant secretion by SP-A is not mediated by an early effect on alveolar type II cell cAMP levels. Pediat. Res. 25 (4): a322
1990 Pian, M.S., and Dobbs, L.G. Pertussis toxin (PT) inhibits terbutaline- and ionomycin- stimulated secretion and terbutaline-stimulated cAMP accumulation in alveolar type II cells. Am. Rev. Respir, Dis. 141: a633
1990 Pian, M.S., and Dobbs, L.G. Evidence that a G protein-mediated process inhibits surfactant secretion in alveolar type II cells from adult rats. J. Cell Biol. 111 (5): 441a
1992 Pian, M.S., and Dobbs, L.G. Evidence for potentiation of terbutaline-stimulated cAMP accumulation and adenylyl cyclase activity by Gbg in isolated pulmonary alveolar type II cells. Molecular Biology of the Cell (3): 243a
1993 Pian M. S. and Dobbs L. G. Potentiation by bg of Gsa-stimulated adenylyl cyclase activity in primary cultures of pulmonary alveolar type II cells. Am. Rev. Respir. Dis. 147:a937
1995 Pian, M.S., and Dobbs, L.G. Pertussis toxin (PTX) inhibits apolipoprotein-stimulated phospholipid secretion in alveolar type II cells. Am. J. Respir. and Crit. Care Med. 151 (4): a652
1995 Pian, M.S., and Dobbs, L.G. Evidence that G proteins regulate apolipoprotein-stimulated phospholipid secretion in alveolar type II cells. Pediat. Res. 37 (4) 396A
1995 Pian, M.S., and Dobbs, L.G. Serum lipoproteins activate guanine nucleotide binding proteins to stimulate surfactant secretion in pulmonary alveolar type II cells. Molecular Biology of the Cell (6): 61a
1996 Dobbs, L. G., Pian, M. S., Dumars, S., and Allen, L. Apical Cell Surface Environment Modulates Phenotypic Expression of Alveolar Epithelial Cells. In Vitro, 32: 17a
1996 Pian, M.S., Dumars, S.M., and Dobbs, L.G. Expression of mRNA for high density lipoprotein binding protein increases in late gestation fetal lung. Molecular Biology of the Cell (7): 625a
1997 Pian, M.S., Allen, L., Dumars, S.M., and Dobbs, L.G. High density lipoprotein binding protein expression increases in late gestation fetal lung. Am. J. Respir. and Crit. Care Med. 155 (4): A840
Top
|
|
